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Literature Synthesis

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Answer: Early SGLT2 initiation after MI with reduced EF is reasonable once hemodynamically stable; multiple RCTs demonstrate reduced HF events. See limitations & subgroup analyses below.

RCTMeta-analysisGuideline
Evidence reviewed October 6, 2025

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CHA₂DS₂-VASc3
ASCVD 10-yr14%
Wells (PE)Low

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  • HFpEF Trials 2019–2025
  • GLP-1 CV Outcomes
  • CKD SGLT2 in non-diabetics
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Outpatient vs inpatient PE?Empiric CAP in allergySGLT2 in non-DM CKD

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Methods last reviewed October 6, 2025

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